Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer

Title Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer

Early development drug formulation on a chip: fabrication of nanoparticles using a microfluidic spray dryer.

Early development drug formulation is exacerbated by increasingly poor bioavailability of potential candidates. Prevention of attrition due to formulation problems necessitates physicochemical analysis and formulation studies at a very early stage during development, where the availability of a new substance is limited to small quantities, thus impeding extensive experiments. Miniaturization of...

Fabrication of hydrophobic drug nanoparticles using a microfluidic spray dryer

We present a technique for fabricating hydrophobic drug nanoparticles using a microfluidic spray dryer. The nanoparticles are formed by evaporative precipitation of the spray in air at room temperature. Using danazol as a model drug, amorphous nanoparticles are yielded with narrow size distribution, 20-60 nm in diameter. As the device geometry allows us to inject two separate solvent streams, t...

Investigating the Treatment of Oil and Gas Produced Water Using a Spray Dryer on a Bench Scale

The current work investigates the performance of a single-stage, bench-scale system using a spray dryer to treat produced water. The produced water is generated in three large reservoirs of Ahvaz, Maroon, and Mansouri fields, which have different compositions but the same high total dissolved solids (TDS) and total organic carbon (TOC). The results of this study indicate that the newly develope...

Fabrication of a modular tissue construct in a microfluidic chip.

By combining microfluidics and soft-lithographic molding of gels containing mammalian cells, a device for three-dimensional (3D) culture of mammalian cells in microchannels was developed. Native components of the extracellular matrix, including collagen or Matrigel, made up the matrix of each molded piece (module) of cell-containing gel. Each module had at least one dimension below approximatel...